SAM-e (S-adenosylmethionine) is a naturally occurring molecule produced by your body and helps support a healthy mood.†  Your SAM-e levels may run low due to various factors such as diet and aging.†

Nature Made SAM-e Complete** can help replenish your SAM-e levels and helps support a healthy mood.  It works to provide the key active methyl donor to support neurotransmitter levels, helping to balance you by acting as mood health support. †^{1 ,2}

• #1 Best Selling Brand of SAM-e supplement*
• Helps support a healthy mood & joint comfort†
• SAM-e can help support a healthy mood in as little as 7-14 days when taken daily†

Who does SAM-e work for?

When your emotions are healthy and balanced, you feel like yourself. Everyday tasks seem easy and you feel like you are in control. However, sometimes emotions can get out of balance, causing you to feel moody.

What most people don’t know is this imbalance can be associated with low levels of SAM-e (S-adenosylmethionine), a naturally occurring molecule produced by your body. SAM-e supplements can help replenish your SAM-e levels and help support a healthy mood.†

Because SAM-e is naturally produced in the body, it also has other vital functions aside from helping to support a healthy mood. One of these other functions is to help support joint comfort, which may naturally deteriorate with physical activity and age, by providing a source of sulfur, which is a critical component of joint tissue.†³

Are there any drug interactions?

Although generally considered as safe, SAM-e has not been evaluated in children or pregnant or lactating women. People with bipolar (manic) depression or who are experiencing severe issues with mood, including thoughts of suicide should not take SAM-e except under a doctor’s supervision.

SAM-e should not be used when taking St. John’s Wort. SAM-e should be used with caution and only under healthcare provider’s supervision when taking MAOI drugs, like Marplan, Nardil, Parnate, Manerix. Individuals on other medications should consult their primary healthcare provider prior to starting SAM-e to check for other potential interactions.

Sam-e is not found in foods but rather produced by the body from ATP and the amino acid methionine. While methionine is found in protein containing foods, consuming more methionine either from methionine rich foods or supplements does not increase SAM-e as the rate limiting step is not methionine supply, but the enzyme that converts methionine to SAM-e.

*#1 Brand of SAM-e supplements based on POS scan data at Food, Drug, Mass and Club.

** Complete because studies have shown that SAM-e helps support a healthy mood & joint comfort.†

Enlarge Image

Suggested Use: Start with 1 tablet per day. The best time to take SAM-e is on an empty stomach at least 30 minutes before a meal. Clinical studies indicate that benefits are most likely evident after 7–14 days of supplementation. If benefits are not achieved within two weeks, you may require a higher level of supplementation. To determine the proper level of supplementation that works for you, gradually increase the number of tablets (maximum 1600 mg /day) until benefits are achieved. Ingredients: S-adenosylmethionine Tosylate Disulfate, Cellulose Gel, Methacrylic Acid Copolymer, Glycerol Behenate, Talc, Triethyl Citrate, Magnesium Stearate, Silicon Dioxide, Color Added, Mannitol, Glycerol Palmitostearate, Medium Chain Triglycerides, Sodium Starch Glycolate, Yellow 5. Interactions: People with bipolar (manic) depression or who are experiencing severe issues with mood, including thoughts of suicide, should not take this or any other product containing SAM-e except under a doctor’s supervision. If you are pregnant or nursing, or taking prescription antidepressant medications, consult your doctor before using this product.   No Yeast or Gluten. Keep out of reach of children. For Consumer Questions or Inquiries call 1-800-276-2878 or visit www.naturemade.com

Nature Made’s Commitment to your Health

Everyone wants a firm foundation to stand upon when making decisions about their health. Since 1971, the Nature Made® brand has been dedicated to supporting your health with a wide range of high quality vitamin supplements. Because of our strong stand on quality and science for more than 40 years, Nature Made has earned recognition and trust among nutrition experts and people just like you.

Safe and Quality Ingredients

Nature Made products are made in accordance with strict Good Manufacturing Practice standards.  Nature Made nutrition supplements are made from carefully selected ingredients from trusted suppliers. Nature Made products are guaranteed to meet high quality standards of purity and potency. When you take the vitamins behind that familiar yellow label, know that you’re taking the best for your health.